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Hydroxychloroquine combination risky for cancer patients with COVID-19: study

Cancer patients with COVID-19 who were treated with a drug combination promoted by U.S. President Donald Trump – hydroxychloroquine – to counter the coronavirus were three times more likely to die within 30 days than those who got either drug alone, U.S. researchers reported on Thursday.

The preliminary results suggest doctors may want to refrain from prescribing the decades-old malaria treatment hydroxychloroquine with the antibiotic azithromycin for these patients until more study is done, researchers said.

“Treatment with hydroxychloroquine and azithromycin were strongly associated with increased risk of death,” Dr. Howard Burris, president of the American Society of Clinical Oncology(ASCO), said in a briefing with reporters on the results.

The drug combination initially was thought to help COVID-19 patients, but recent data has cast doubt on the regimen.

The preliminary findings, to be presented this week at ASCO’s virtual scientific meeting, show that the combination may pose a significant risk to cancer patients.

“Taking the combination gives a three times increased risk of dying within 30 days of any cause,” Dr. Jeremy Warner of Vanderbilt University Medical System told reporters.

Trump, who has often promoted hydroxychloroquine, in a March 21 tweet called the combination potentially “one of the biggest game changers in the history of medicine.”

That was based on a study of fewer than 40 patients in the International Journal of Antimicrobial Agents. More recent studies have shown little or no benefit and increased risks.

Warner and colleagues analyzed data on 925 patients with cancer who became infected with the coronavirus between March and April. Thirteen percent of the patients died within 30 days of their diagnosis.

Overall, patients whose cancers were actively progressing at the time of infection were five times more likely to die within 30 days than those who were in remission or had no current evidence of cancer.

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Meeta Ramnani
Meeta Ramnani
Meeta develops credible content about various markets based on deep research, opinions from experts and inputs from industry leaders. As the managing editor at Smart Industry News, she assures that every piece of news and article adds to the knowledge of decision makers. An avid bike rider, Meeta, is a postgraduate from Indian Institute of Journalism and New Media (IIJNM) Bangalore, where her specialization was Business Journalism. She carries experience from mainstream print media including The Times Group and Sakal Media Group.
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