Allergy & Immunology Lifestyle and Mind Press

New NCCN Guidelines to Recognize Side-Effects from Immunotherapy

The National Comprehensive Cancer Network® (NCCN®) has announced the publication of new NCCN Guidelines for Patients®: Immunotherapy Side Effects—Immune Checkpoint Inhibitors. Over the past decade, immunotherapy—a treatment that helps the patient’s own immune system recognize and destroy cancer cells—has become an important option for some cancers, and adds to traditional approaches like chemotherapy, radiation, and surgery. Often, immunotherapy is fairly well tolerated. However, emerging research shows immunotherapy can result in different side effects than chemotherapy, including severe adverse events. In fact, researchers have found 43% of patients have stopped treatment with immune checkpoint inhibitors (or ICIs, a common type of immunotherapy), as a result of serious side effects.

“These NCCN Guidelines for Patients are designed to educate patients and to help them recognize immune side effects so that effective interventions can be started promptly,” explained Seattle Cancer Care Alliance’s John A. Thompson, MD, Professor of Medicine, University of Washington, Member, Fred Hutchinson Cancer Research Center, and Chair, NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Panel for Management of Immunotherapy-Related Toxicities. “Immune checkpoint inhibitors have revolutionized our approach to the treatment of cancer. ICIs are now approved by the FDA for treating more than a dozen forms of cancer and the list is growing every year. However, by virtue of stimulating the patient’s immune white blood cells, ICI therapy sometimes causes serious side-effects that mimic autoimmune disease, including significant rash and/or inflammation of the thyroid, liver, lungs, nervous system, glandular system, heart, or other organs.”

The NCCN Guidelines for Patients are easy-to-understand, lay-language versions of the evidence-based, expert-consensus clinical practice guidelines used by health care providers all over the globe. They enable patients and caregivers to get a better idea of their treatment options in order to make informed decisions about their care. Features include patient-friendly illustrations, suggested questions to ask, and a glossary of terms and acronyms. A recent independent study of the NCCN Guidelines for Patients: Prostate Cancer found them to be among the most reliable and trustworthy sources for online health information.

NCCN Guidelines for Patients are available for free online at, or via the NCCN Patient Guides for Cancer App, thanks to funding from the NCCN Foundation®. Printed copies are available at for a nominal fee. The immunotherapy patient guidelines have been endorsed by Be The Match/National Marrow Donor Program® (NMDP), Good Days, The Leukemia & Lymphoma Society (LLS), and Stupid Cancer.

“The Leukemia & Lymphoma Society is endorsing these NCCN materials about immunotherapy because we believe that patients should understand all aspects of their care,” said Meredith Barnhart, Director of the Information Resource Center of The Leukemia & Lymphoma Society. “As patients understand more about managing toxicity, they can take better care of themselves and be prepared to ask their healthcare team the right questions to increase their quality of life.”

Meeta Ramnani
Meeta Ramnani
Meeta develops credible content about various markets based on deep research, opinions from experts and inputs from industry leaders. As the managing editor at Smart Industry News, she assures that every piece of news and article adds to the knowledge of decision makers. An avid bike rider, Meeta, is a postgraduate from Indian Institute of Journalism and New Media (IIJNM) Bangalore, where her specialization was Business Journalism. She carries experience from mainstream print media including The Times Group and Sakal Media Group.